Can a Christian lose their salvation? Is the 'once saved always saved' doctrine biblical?

The concept that once you are saved you cannot be lost is unbiblical.

Indeed, the Bible has several examples of people who were saved relationship with God and were even Spirit-filled—but then they turned from the Lord.

For instance, King Saul was chosen by the Lord, anointed, filled with the Spirit, but he became proud and grieved away the Holy Spirit and eventually took his own life in despair. Judas was sent out preaching with the other 11 disciples, but he kept clinging to covetousness until he denied the Lord and sold Him. Judas lost his salvation, his relationship with the Lord.

Ezekiel 18:24 says, “But when the righteous man turns away from his righteousness, and commits iniquity, and does according to all the abominations that the wicked man does, shall he live? All his righteousness that he has done shall not be mentioned: in his trespass that he has trespassed, and in his sin that he has sinned, in them shall he die.” In other words, a person who was righteous can indeed turn away and be lost. In Hebrews 10:23, 24, Paul says, “Let us hold fast the profession of our faith without wavering.” Once a person is saved, why would they need to hold fast? He goes on to add, “Let us consider one another to provoke unto love and good works, for if we sin willfully after we have received a knowledge of the truth there remains no more sacrifice for sins but a certain fearful looking forward to of judgment.”

The Bible doesn’t tell say that once we’re saved, we turn from all responsibility of continuing to hold onto God’s hand. Jesus will never let go of us, but we can let go of Him if we choose. The danger of the teaching once-saved-always-saved is that it takes away free will. But we’re always free to choose to love the Lord or walk away.

“Christian, know ye not that they which run in a race run all, but one receiveth the prize? So run, that ye may obtain. And every man that striveth for the mastery is temperate in all things. Now they do it to obtain a corruptible crown; but we an incorruptible. I therefore so run, not as uncertainly; so fight I, not as one that beateth the air; But I keep under my body, and bring it into subjection: lest that by any means, when I have preached to others, I myself should be a castaway” (1 Corinthians 9:24–27). In other words, Paul is saying that it was possible, even though he had this spirit-filled saved relationship, to be cast away.
On the other extreme, some think that you need to walk every day in doubt of your relationship with the Lord. But the Bible is clear that you can have an assurance of your relationship with Him. The Bible says you can know that He who has begun a good work in you will perform it to the day of Jesus; He is the Author and Finisher of your faith, that you might know that you have everlasting life.

God does not want us to live in fear. He said that we can know we have eternal life. We can know as long as we abide in Him, we have nothing to be afraid of. It’s when we take our hand out of His hand and we choose to turn from His will and go our own way that we are in danger. That’s why I believe that it’s important for us to daily rededicate our lives. Paul said, “I die daily.” He chose every day to say no to living for myself, to die to self, and be born again unto God. On a daily basis, rededicate yourself to God. It doesn’t mean that you’re lost and saved, lost and saved, lost and saved, like a roller coaster. Indeed, dying to yourself daily means that you will keep your relationship with God.

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